Download Adrenal Glands Diagnostic Aspects and Surgical Therapy by Dimitrios A. Linos, Jon A. van Heerden PDF

By Dimitrios A. Linos, Jon A. van Heerden

- Over 2 hundred beautiful illustrations, starting from intraoperative pictures, line drawings, diagnostic pictures, pathology slides, tables and graphs can be found to make every one case mentioned understandable and simple to follow.
- conventional and novel healing options are introducedand the newest advancements in minimal-access operative recommendations are mentioned and reviewed.
- makes a speciality of a teamwork orientated strategy that identifies the mandatory communications among the numerous clinical disciplines whilst facing adrenal issues.

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In addition, neurotransmitters from parallel neuronal systems, like serotonin, acetylcholine,catecholamines (a1-receptors) and neuropeptide Y, stimulate CRH secretion [18, 44], whereas the GABA/benzodiazepine system and endogenous opioids exert inhibitory effects [17, 82]. It is obvious that CRH secretion is tightly interweaved in the neurocircuitry of stress, which utilizes a complex network of interacting pathways in order to initiate and orchestrate an effective response to stressors. In the hormonal cascade of the HPA axis activation, CRH exerts its effect on pituitary ACTH secretion via high-affinity transmembrane CRH receptors on the corticotrophs that couple to guanine nucleotidebinding proteins and stimulate the release of ACTH by a cAMP-dependent mechanism [2].

Vale W, Vaughan J, Smith M, et al (1983) Effects of synthetic ovine corticotropin-releasing factor, glucocorticoid, catecholamines, neuro-hypophyseal peptides, and other substances on cultured corticotropic cells. Endocrinology 113:1121–1131 125. Valentino RJ, Foote SL, Aston-Jones G (1983) Corticotropin-releasing hormone activates noradrenergic neurons of the locus ceruleus. Brain Res 270:363–367 126. Vamvakopoulos NC, Chrousos GP (1993) Evidence of direct estrogen regulation of human corticotropin releasing hormone gene expression: Potential implica- 127.

Brain Res 270:363–367 126. Vamvakopoulos NC, Chrousos GP (1993) Evidence of direct estrogen regulation of human corticotropin releasing hormone gene expression: Potential implica- 127. 128. 129. 130. 131. 132. 133. tions for the sexual dimorphism of the stress response and immune/inflammatory reaction. J Clin Invest 92: 1896–1902 Vanderpool J, Rosenthal N, Chrousos GP, et al (1991) Abnormal pituitary-adrenal responses to corticotropinreleasing hormone in patients with seasonal affective disorder: Clinical and pathophysiological implications.

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