Download Anaerobiosis and stemness : an evolutionary paradigm for by Zoran Ivanovic, Marija Vlaski-Lafarge PDF

By Zoran Ivanovic, Marija Vlaski-Lafarge

Anaerobiosis and Stemness: An evolutionary paradigm offers a context for figuring out the numerous complexities and evolutionary gains of stem cells and the scientific implications of anaerobiosis stem cells. Combining theoretical and experimental wisdom, the authors supply a huge realizing of ways the absence or low focus of oxygen can play an influential position within the upkeep and self-renewal of stem cells and stem telephone differentiation. This knowing has medical implications for the fields of regenerative medication, melanoma biology and transplantation, in addition to telephone engineering and telephone treatment. Anaerobiosis and Stemness is a crucial source for stem cellphone and developmental biologists alike, in addition to oncologists, melanoma biologists, and researchers utilizing stem cells for regeneration.

  • Highlights the molecular and evolutionary positive aspects of stem cells which lead them to so vital to all organic research
  • Explores equipment of isolation, characterization, activation, and upkeep of stem cells
  • Includes versions for medical program in regenerative medication, melanoma treatment, and transplantation

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Additional resources for Anaerobiosis and stemness : an evolutionary paradigm for therapeutic applications

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004;23(118):149–61. [37] Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007;13(1):685–97. [38] van der Wath RC, Wilson A, Laurenti E, Trumpp A, Liò P. Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics.

Similarly, the faster proliferation and better maintenance of undifferentiated characteristics and the differentiation potential of the human Wharton’s jelly-derived MStroC was evidenced in 2–3% O2 compared to 20–21% O2 cultures from 1 to 9 passages (the passage 0 appears to have been performed in 20–21% O2) [102], which was associated with a gene expression profile consistent with mesodermal/endothelial fate: several stem cells markers and early mesodermal/endothelial genes such as DESMIN, CD34, and ACTC were up-­regulated (the total MStroC population analyzed).

Use of umbilical cord blood gas analysis in the assessment of the newborn. Arch Dis Child Fetal Neonatal Ed 2007;92:F430–4. [16] Chen EY, Fujinaga M, Giaccia AJ. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology 1999;60:215–25. [17] Lord EM, Harwell L, Koch CJ. Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res 1993;53:5721–6. [18] Lee YM, Jeong CH, Koo SY, Son MJ, Song HS, Bae SK, et al.

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