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By Malcolm Carruthers

Simply what's the andropause? even supposing reputation of the andropause notion through the scientific group is becoming, it truly is nonetheless a hotly debated factor. yet as a hectic clinician you've gotten sufferers to regard and also you want info. So the place are you able to locate the data you want to comprehend, diagnose, and deal with this situation? Androgen Deficiency within the grownup Male: factors, prognosis and therapy distills the data got by way of writer Dr. Malcolm Carruthers in his 25 years of study and scientific event in diagnosing and treating the andropause right into a complete, distinctive scientific resource.

Dr. Carruthers files the heritage of the quest for testosterone therapy from antiquity to the awarding of the Nobel Prize to Adolf Butenandt and Leopold Ruzicka for synthesizing testosterone and patenting its creation a few 4,000 years later. He discusses the explanations of androgen deficiency, the male menopause or andropause, and up to date advances in its prognosis. The textual content comprises studies of the literature in every one part and a fund of bibliographic references gleaned from the author's years of study during this box. this mixture of positive factors makes Androgen Deficiency within the grownup Male: explanations, analysis and therapy a useful and useful medical consultant, a whole and precise reference quantity, and a cohesive and readable textbook.

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Example text

Ampoules containing 1 cc of sesame oil, packaged similarly to the original testos- HISTORY OF TESTOSTERONE 31 terone propionate, were substituted without the patient’s knowledge in several cases. No improvement was noted in any case. As well as recommending pellet implants for long-term treatment, they made two final important points in this historic paper. ’ We will see later why the andropause may have become more common over half a century and yet remains under-recognized and -treated. Dr Tiberius Reiter Starting in 1950, a German physician who trained in Berlin, Edinburgh and Glasgow, but set up in private practice in London’s Harley Street, used testosterone pellet implants to treat men in their 40s, 50s, 60s and 70s suffering what he called IDUT syndrome.

While recognizing the overriding importance of the first of these, because in most state medical systems availability is limited by cost, most of the patients describe the high price of most testosterone preparations as being the limiting factor in the uptake of this form of treatment. Where do you stand on concern about potential risk of prostatic disease? The responses to this question were most reassuring to doctors and patients alike. Over 75% of delegates said they would start treatment but carefully monitor the level of prostate-specific antigen, 15% thought the potential benefits outweigh the potential risks, 6% would await the outcome of stringent risk versus benefit analyses and only 2% would not consider prescribing it because of the concerns about prostatic disease.

This first well-documented successful hormone replacement therapy inaugurated a century of attempts to use testicular extracts or implants to rejuvenate men. However, most of these attempts were either of doubtful effectiveness, mainly relying on the placebo effect of giving patients a novel form of treatment, or fraudulent confidence tricks based on the instinctive wish for a long and active life. It is difficult to this day to decide whether doctors offering rejuvenation treatments are ‘leading-edge pioneers’ or ‘medical buccaneers’ who navigate ‘this poorly charted sea of medical research’.

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